The cognitive deficit induced by Al nanoparticle ingestion is associated with hippocampal inflammation in mice

Background Although, both environmental and genetic factors are known as the predispositions to AD development, each of these suggested acts via increasing Al content brain tissue. nanoparticles newer nanomaterials that have been significantly exposed human body. When reaches nanosize, it may display different characteristics from natural Al, its potential influence on body function is an interesting aspect research particles might more negative impact health. Activation microglia expression inflammatory cytokine IL-1 (interleukin-1) in used hallmarks inflammation. Our recent findings suggest administration nano-Al for a short period 5 days can cause memory impairment. Given importance neuroinflammation Alzheimer’s pathology, question was whether 5-day intake could lead changes hippocampus. Method Adult male NMRI mice were treated with doses 10 mg/kg/oral gavage days. The test session novel object recognition (NOR) task performed day 5. Following NOR test, hippocampi isolated. Considering key roles activation IL-1β neuroinflammation, levels hippocampal iba-1 (as speciefic marker microglial activation) determined using western blot studies. Result results showed oral mg/kg impairs mice. Moreover, impairing effect coincided dose dependent increase iba-1. It also increased Conclusion This study low mg/ kg ingested induces